Following the account of humanity's growing wickedness and the scattering of nations at Babel, Genesis introduces Abraham as the man through whom God will begin a new chapter in His relationship with humanity.
God calls Abraham to leave his homeland and promises to make him the father of a great nation. The promise extends beyond Abraham's immediate descendants: all the families of the earth will receive blessing through him.
In Genesis 22, following Abraham's willingness to offer Isaac, God reaffirms the promise that the nations will be blessed through Abraham's offspring.