Wochner et al. — Ribozyme-Catalyzed Transcription
Author:
Aniela Wochner; James Attwater; Alan Coulson; Philipp Holliger
Ribozyme-Catalyzed Transcription of an Active Ribozyme • 2011
Journal Article
Neutral
Used in this investigation
Evidence
-
The RNA World
—
Experimental Support
-
Catalytic RNA and Ribozymes
—
Scientific Foundation
Patel et al. — Common Origins of RNA, Protein and Lipid Precursors
Author:
Bhavesh H. Patel; Claudia Percivalle; Dougal J. Ritson; Colm D. Duffy; John D. Sutherland
Common Origins of RNA, Protein and Lipid Precursors in a Cyanosulfidic Protometabolism • 2015
Journal Article
Neutral
Used in this investigation
Evidence
-
The Chemical Building Blocks of Life
—
Scientific Foundation
-
Concentrating and Organizing Prebiotic Molecules
—
Chemical Network
-
From Building Blocks to Biological Polymers
—
Precursor Context
Explanations
-
Chemical Evolution and Natural Processes
—
Experimental Support
Questions & Objections
-
Are Probability Arguments About the Origin of Life Misleading?
—
Experimental Support
Damer and Deamer — Hot Spring Hypothesis
Author:
Bruce Damer; David Deamer
The Hot Spring Hypothesis for an Origin of Life • 2020
Scientific Review
Neutral
Used in this investigation
Evidence
-
Environments Proposed for the Origin of Life
—
Origin Model
Horning and Joyce — Amplification of RNA by an RNA Polymerase Ribozyme
Author:
David P. Horning; Gerald F. Joyce
Amplification of RNA by an RNA Polymerase Ribozyme • 2016
Journal Article
Neutral
Used in this investigation
Evidence
-
Nonenzymatic RNA Replication
—
Experimental Comparison
-
Catalytic RNA and Ribozymes
—
Experimental Advance
Koonin — Frozen Accident and the Genetic Code
Author:
Eugene V. Koonin
Frozen Accident Pushing 50: Stereochemistry, Expansion, and Chance in the Evolution of the Genetic Code • 2017
Scientific Review
Neutral
Used in this investigation
Evidence
-
The Origin of the Genetic Code and Translation
—
Scientific Analysis
Koonin and Novozhilov — Origin and Evolution of the Genetic Code
Author:
Eugene V. Koonin; Artem S. Novozhilov
Origin and Evolution of the Genetic Code: The Universal Enigma • 2009
Scientific Review
Neutral
Used in this investigation
Evidence
-
The Origin of Biological Information
—
Scientific Foundation
-
The Origin of the Genetic Code and Translation
—
Scientific Foundation
Questions & Objections
-
Is Biological Information Just a Misleading Analogy?
—
Scientific Foundation
Koonin and Novozhilov — Universal Genetic Code
Author:
Eugene V. Koonin; Artem S. Novozhilov
Origin and Evolution of the Universal Genetic Code • 2017
Scientific Review
Neutral
Used in this investigation
Evidence
-
The Origin of Biological Information
—
Evolutionary Model
-
The Origin of the Genetic Code and Translation
—
Origin Model
Questions & Objections
-
Is Biological Information Just a Misleading Analogy?
—
Evolutionary Model
Szostak — The Eightfold Path to Non-Enzymatic RNA Replication
Author:
Jack W. Szostak
The Eightfold Path to Non-Enzymatic RNA Replication • 2012
Scientific Review
Neutral
Used in this investigation
Evidence
-
The RNA World
—
Replication Problem
-
Nonenzymatic RNA Replication
—
Scientific Foundation
Explanations
-
RNA-First and Integrated Origin Models
—
Replication Problem
Questions & Objections
-
Can Natural Selection Begin Before the First Cell?
—
Replication Context
Fine and Pearlman — RNA-Focused Origin-of-Life Synthesis
Author:
Jacob L. Fine; Ronald E. Pearlman
On the Origin of Life: An RNA-Focused Synthesis and Narrative • 2023
Scientific Review
Neutral
Used in this investigation
Evidence
-
The RNA World
—
Scientific Foundation
-
Nonenzymatic RNA Replication
—
Broader Context
-
Catalytic RNA and Ribozymes
—
Broader Context
Explanations
-
RNA-First and Integrated Origin Models
—
Scientific Foundation
-
Purposeful Design
—
Scientific Context
-
An Explanation Not Yet Known
—
Future Research
Schrum et al. — The Origins of Cellular Life
Author:
Jason P. Schrum; Ting F. Zhu; Jack W. Szostak
The Origins of Cellular Life • 2010
Scientific Review
Neutral
Used in this investigation
Evidence
-
Membranes and the First Protocells
—
Integrated System
-
Metabolism and the Capture of Energy
—
Broader Context
-
From Chemistry to an Evolvable Living System
—
Scientific Foundation
Explanations
-
RNA-First and Integrated Origin Models
—
Protocell Integration
Questions & Objections
-
Haven't Scientists Already Created Life in the Laboratory?
—
Experimental Context
Forsythe et al. — Wet-Dry Cycles and Peptide Formation
Author:
Jay G. Forsythe; Sheng-Sheng Yu; Irena Mamajanov; Martha A. Grover; Ramanarayanan Krishnamurthy; Facundo M. Fernández; Nicholas V. Hud
Ester-Mediated Amide Bond Formation Driven by Wet-Dry Cycles: A Possible Path to Polypeptides on the Prebiotic Earth • 2015
Journal Article
Neutral
Used in this investigation
Evidence
-
Concentrating and Organizing Prebiotic Molecules
—
Environmental Mechanism
-
From Building Blocks to Biological Polymers
—
Scientific Foundation
Questions & Objections
-
Are Probability Arguments About the Origin of Life Misleading?
—
Experimental Example
Sutherland — Studies on the Origin of Life
Author:
John D. Sutherland
Studies on the Origin of Life — The End of the Beginning • 2017
Scientific Review
Neutral
Used in this investigation
Evidence
-
The Chemical Building Blocks of Life
—
Broader Context
-
Concentrating and Organizing Prebiotic Molecules
—
Scientific Foundation
-
From Building Blocks to Biological Polymers
—
Broader Context
-
Environments Proposed for the Origin of Life
—
Chemical Context
-
From Chemistry to an Evolvable Living System
—
Chemical Integration
Explanations
-
Chemical Evolution and Natural Processes
—
Scientific Foundation
-
An Explanation Not Yet Known
—
Research Context
Questions & Objections
-
Are Probability Arguments About the Origin of Life Misleading?
—
Scientific Foundation
-
Is Intelligent Design Just a God-of-the-Gaps Argument?
—
Research Context
Ruiz-Mirazo et al. — Chemical Roots of Biological Evolution
Author:
Kepa Ruiz-Mirazo; Carlos Briones; Andrés de la Escosura
Chemical Roots of Biological Evolution: The Origins of Life as a Process of Development of Autonomous Functional Systems • Open Biology • 2017
Scientific Review
Neutral
DOI:
10.1098/rsob.170050
Used in this investigation
Questions & Objections
-
Can Natural Selection Begin Before the First Cell?
—
Scientific Foundation
-
Could Future Origin-of-Life Discoveries Eliminate the Design Argument?
—
Developing Models
Rothschild et al. — Building Synthetic Cells
Author:
Lynn J. Rothschild; Nils J. H. Averesch; Elizabeth A. Strychalski; Felix Moser; John I. Glass; Rolando Cruz Perez; Ibrahim O. Yekinni; Brooke Rothschild-Mancinelli; Garrett A. Roberts Kingman; Feilun Wu; Jorik Waeterschoot; Ion A. Ioannou; Michael C. Jewett; Allen P. Liu; Vincent Noireaux; Carlise Sorenson; Katarzyna P. Adamala
Building Synthetic Cells—From the Technology Infrastructure to Cellular Entities • ACS Synthetic Biology • 2024
Scientific Review
Neutral
DOI:
10.1021/acssynbio.3c00724
Used in this investigation
Questions & Objections
-
Haven't Scientists Already Created Life in the Laboratory?
—
Scientific Foundation
-
Could Future Origin-of-Life Discoveries Eliminate the Design Argument?
—
Scientific Foundation
Hanczyc et al. — Primitive Cellular Compartments
Author:
Martin M. Hanczyc; Shelly M. Fujikawa; Jack W. Szostak
Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division • 2003
Journal Article
Neutral
Used in this investigation
Evidence
-
Membranes and the First Protocells
—
Scientific Foundation
Explanations
-
Self-Organization and Emergent Systems
—
Experimental Example
Lane and Martin — The Origin of Membrane Bioenergetics
Author:
Nick Lane; William F. Martin
The Origin of Membrane Bioenergetics • 2012
Journal Article
Neutral
Used in this investigation
Evidence
-
Metabolism and the Capture of Energy
—
Origin Model
-
Environments Proposed for the Origin of Life
—
Metabolic Context
Adamski et al. — From Self-Replication to Replicator Systems
Author:
Paul Adamski; Marcel Eleveld; Ankush Sood; Ádám Kun; András Szilágyi; Tamás Czárán; Eörs Szathmáry; Sijbren Otto
From Self-Replication to Replicator Systems en Route to de Novo Life • 2020
Scientific Review
Neutral
Used in this investigation
Evidence
-
From Chemistry to an Evolvable Living System
—
Integrated System
Explanations
-
Chemical Evolution and Natural Processes
—
Integration Problem
-
RNA-First and Integrated Origin Models
—
Integrated System
-
Self-Organization and Emergent Systems
—
Systems Context
-
Purposeful Design
—
Scientific Foundation
-
An Explanation Not Yet Known
—
Scientific Foundation
Questions & Objections
-
Haven't Scientists Already Created Life in the Laboratory?
—
Integration Problem
-
Can Natural Selection Begin Before the First Cell?
—
Replicator Evolution
-
Is Intelligent Design Just a God-of-the-Gaps Argument?
—
Scientific Foundation
-
Could Future Origin-of-Life Discoveries Eliminate the Design Argument?
—
Future Research
Mansy et al. — Genetic Polymer Synthesis in a Model Protocell
Author:
Sheref S. Mansy; Jason P. Schrum; Mathangi Krishnamurthy; Sylvia Tobé; Douglas A. Treco; Jack W. Szostak
Template-Directed Synthesis of a Genetic Polymer in a Model Protocell • 2008
Journal Article
Neutral
Used in this investigation
Evidence
-
Membranes and the First Protocells
—
Experimental Advance
Meyer — Signature in the Cell
Author:
Stephen C. Meyer
Signature in the Cell: DNA and the Evidence for Intelligent Design • 2009
Id Source
Supports Design
Used in this investigation
Evidence
-
The Origin of Biological Information
—
Design Interpretation
-
The Origin of the Genetic Code and Translation
—
Design Interpretation
-
From Chemistry to an Evolvable Living System
—
Design Interpretation
Explanations
-
Purposeful Design
—
Design Interpretation
Questions & Objections
-
Is Biological Information Just a Misleading Analogy?
—
Design Interpretation
-
Is Intelligent Design Just a God-of-the-Gaps Argument?
—
Design Interpretation
-
Could Future Origin-of-Life Discoveries Eliminate the Design Argument?
—
Design Interpretation
Sojo et al. — Origin of Life in Alkaline Hydrothermal Vents
Author:
Victor Sojo; Barry Herschy; Alexandra Whicher; Eloi Camprubí; Nick Lane
The Origin of Life in Alkaline Hydrothermal Vents • 2016
Scientific Review
Neutral
Used in this investigation
Evidence
-
Environments Proposed for the Origin of Life
—
Origin Model
Martin — Early Evolution of Biological Energy Conservation
Author:
William F. Martin
Hydrogen, Metals, Bifurcating Electrons, and Proton Gradients: The Early Evolution of Biological Energy Conservation • 2012
Scientific Review
Neutral
Used in this investigation
Evidence
-
Metabolism and the Capture of Energy
—
Scientific Foundation
Hordijk and Steel — Autocatalytic Networks at the Basis of Life
Author:
Wim Hordijk; Mike Steel
Autocatalytic Networks at the Basis of Life's Origin and Organization • 2018
Scientific Review
Neutral
Used in this investigation
Explanations
-
Self-Organization and Emergent Systems
—
Scientific Foundation
