Our knowledge of molecular evolution is incomplete. Critics therefore warn that unexplained steps in the history of a molecular machine should not be treated as evidence of design. Future discoveries may reveal natural pathways that are presently unknown.
Science has repeatedly explained phenomena that were once mysterious. If design is inferred whenever a natural pathway has not yet been reconstructed, the argument can retreat whenever scientific knowledge advances.
This objection is valid against a design argument based only upon missing evolutionary explanations. A responsible design case must therefore do more than identify gaps.
The positive question is whether molecular systems contain characteristics for which intelligent causation has independent explanatory relevance: functional information, coordinated organization, assembly requirements, control systems, and arrangements directed toward specific functional outcomes.
Evolutionary explanations and design arguments should therefore be compared by what they positively explain, not merely by what the competing explanation has not yet explained.
What positive observations could distinguish evidence of intelligent organization from a molecular system whose evolutionary history simply remains incomplete?