Possible Explanation

Chemical Evolution and Natural Processes

The Origin of Life  • Chemical Evolution
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 The Explanation

One explanation is that life emerged through a long sequence of ordinary chemical processes operating on the early Earth.

On this view, simple chemicals produced increasingly complex organic compounds. Environmental conditions concentrated some of those compounds and promoted further reactions. Molecules capable of catalysis, replication, compartmentalization, and energy use eventually became connected into systems upon which natural selection could act.

Experiments have demonstrated important parts of this general picture. Researchers have produced biologically relevant organic compounds under plausible prebiotic conditions, formed polymers through nonbiological chemistry, constructed membrane vesicles, developed catalytic RNA molecules, and investigated several mechanisms of molecular replication.

What has not been experimentally reconstructed is the complete transition from nonliving chemistry to an autonomous system capable of sustained Darwinian evolution.

Chemical evolution therefore provides a broad natural framework for origin-of-life research while leaving important questions about the sequence and integration of the required processes unresolved.

 Research Sources

Sutherland — Studies on the Origin of Life
John D. Sutherland • 2017
Reviews experimental progress in prebiotic chemistry and efforts to connect individual reactions into chemically coherent pathways toward living systems.
Primary scientific context for chemical evolution. Sutherland surveys progress in constructing plausible chemical pathways while distinguishing successful individual reactions from a complete origin-of-life scenario.
Scientific Foundation
Patel et al. — Common Origins of RNA, Protein and Lipid Precursors
Bhavesh H. Patel; Claudia Percivalle; Dougal J. Ritson; Colm D. Duffy; John D. Sutherland • 2015
Demonstrates related prebiotic chemistry capable of producing precursors relevant to RNA, proteins, and lipids.
Provides experimental evidence that ordinary chemistry under specified conditions can produce several classes of biologically relevant precursor molecules.
Experimental Support
Adamski et al. — From Self-Replication to Replicator Systems
Paul Adamski; Marcel Eleveld; Ankush Sood; Ádám Kun; András Szilágyi; Tamás Czárán; Eörs Szathmáry; Sijbren Otto • 2020
Examines the additional steps required to move from self-replicating chemistry toward systems combining replication, metabolism, compartmentalization, and Darwinian evolution.
Important qualification to the broad chemical-evolution explanation. Demonstrating individual chemical processes does not by itself demonstrate their functional integration into an autonomous evolving system.
Integration Problem