Evidence Record

Biological Information Processing

Information Processing  •  Patterns of Design in Living Systems
A Visit With Jesus

Cells receive molecular signals, distinguish among them, integrate information, and produce coordinated responses.

The Investigative Question

In what sense do living systems process information?

What We Observe

Cells respond differently to nutrients, hormones, environmental signals, developmental cues, damage, and signals from neighboring cells.

Scientific Background

Signal-transduction networks use receptors, molecular switches, phosphorylation, second messengers, transcription factors, and other mechanisms to transmit and transform biological signals.

Why It Matters

Information-processing language can provide useful quantitative and conceptual tools for understanding how cells distinguish signals and coordinate responses.

What Is Known

Specific signaling pathways and regulatory networks have been characterized experimentally, and mathematical methods can measure aspects of signal transmission and cellular decision-making.

What Is Proposed

Systems biology models cellular signaling as interacting networks capable of filtering, amplification, integration, switching, and other forms of signal processing.

What Remains Uncertain

The word "information" is used in several different ways in biology. Care is needed when moving from measurable information in signaling or genetics to philosophical claims about information and design.

Design Relevance

Information processing is central to many Intelligent Design arguments. The investigation should distinguish measurable biological information processing from broader claims about the ultimate origin of biological information.

Assessment

Cells demonstrably transmit and process signals. Whether those processes provide evidence for design requires an additional argument concerning their origin and organization.

Research Sources

Purvis and Lahav — Cellular Information through Signaling Dynamics
Jeremy E. Purvis; Galit Lahav • Cell • 2013
Use: Signaling Dynamics
Relevance: Provides a framework for understanding how cells can encode and decode information through the temporal dynamics of signaling molecules.
DOI: 10.1016/j.cell.2013.02.005
Papin et al. — Cellular Signalling Networks
Jason A. Papin; Tony Hunter; Bernhard O. Palsson; Shankar Subramaniam • Nature Reviews Molecular Cell Biology • 2005
Use: Signaling Networks
Relevance: Provides a systems-level treatment of cellular signaling networks and the methods used to reconstruct and analyze their organization and behavior.
DOI: 10.1038/nrm1570
Makadia et al. — Intracellular Information Processing
Hirenkumar K. Makadia; James S. Schwaber; Rajanikanth Vadigepalli • PLOS Computational Biology • 2015
Use: Dynamic Information Processing
Relevance: Examines how temporal features of intracellular signals can carry information that is reflected in downstream transcriptional regulatory activity.
DOI: 10.1371/journal.pcbi.1004563