Information Replication
The Origin of Biological Information
The sequence of nucleotides in genetic molecules affects their structure and function. Origin-of-life research therefore includes the question of how useful sequence-dependent information first emerged and became heritable.
Integrated System
From Chemistry to an Evolvable Living System
The central origin-of-life problem is ultimately one of integration: how prebiotic chemistry produced a bounded system in which information, replication, chemical function, energy use, and reproduction worked together well enough for Darwinian evolution to begin.
Biological Information
Functional Information in DNA Sequences
The biological importance of DNA depends upon particular sequences performing useful functions. Some sequences specify molecular products, while others help regulate when and where those products are produced.
Integrated System
Biological Information as an Integrated System
Biological information operates through an integrated system. DNA stores sequences, genes are transcribed into RNA, codons are interpreted through adaptor molecules, amino acids are selected and attached, ribosomes translate sequences into proteins, and multiple mechanisms maintain sufficient fidelity for the system to function.