After Melchizedek blesses Abraham in Genesis 14, Abraham's victorious return is marked by an encounter with a priest-king who brings out bread and wine. Christians have sometimes seen these elements as a foreshadowing of the bread and wine used by Jesus at the Last Supper. The resemblance is suggestive, especially because Melchizedek later becomes an important type of Christ in Psalm 110 and Hebrews.

Nevertheless, Genesis 14 does not state that the bread and wine are prophetic symbols of the Lord's Supper, and the New Testament does not explicitly make that particular connection. The relationship should therefore be presented as traditional Christian typology rather than direct prophecy. In Matthew 26:26-29 Jesus gives bread and wine a new covenant significance centered on His body and blood. Read within the wider biblical association between Melchizedek and Christ, the earlier meal can appropriately be viewed as an anticipatory image, while the Last Supper provides the distinctly Christian meaning.