Psalm 22:14 describes the sufferer's life as being poured out like water, with his body weakened and his heart melting within him. The language is poetic and communicates extreme physical and emotional collapse. It does not specifically mention blood or the piercing of the side.

John 19:34 records a soldier piercing Jesus' side, after which blood and water flowed out. Christians have sometimes connected that detail with Psalm 22:14, but John does not cite the psalm at this point and the correspondence should not be made more precise than the text permits. The stronger relationship is that Jesus' crucifixion embodies the bodily dissolution and complete pouring out of life described by the psalm. The blood and water in John provide a vivid historical detail of His death, while Psalm 22 supplies poetic language for the extremity of His suffering.