Deuteronomy 18:19 attaches a solemn consequence to the promise of the coming prophet. Because this prophet speaks God's own words, refusal to listen to him is ultimately refusal to listen to God. The authority of the messenger derives from the One who sends him, and God declares that He Himself will hold the disobedient hearer accountable.

Acts 3:22-23 directly quotes this passage in Peter's sermon concerning Jesus. Peter identifies Jesus as the Prophet promised through Moses and warns that those who refuse to listen to Him face exclusion from God's people. This is one of the clearest direct New Testament applications of an Old Testament messianic passage. The fulfillment is not based merely upon similarities between Moses and Jesus; Peter explicitly invokes Moses' words and applies both the promise and its warning to Christ. The passage therefore emphasizes not only Jesus' prophetic office but also the necessity of responding faithfully to His message.