Daniel 9:26 says that after the specified sixty-two sevens an "anointed one" will be cut off and have nothing, followed by the destruction of the city and sanctuary by the people of a coming ruler. In a traditional Christian messianic reading, the language of the Anointed One being cut off is understood as anticipating the violent death of Christ.

Matthew 16:21 records Jesus telling His disciples that He must go to Jerusalem, suffer, be killed, and be raised, while Matthew 21:38-39 portrays the wicked tenants seizing and killing the owner's son. These passages fit the Christian identification of Jesus as the Anointed One who is cut off. Daniel does not specify crucifixion or all the circumstances of Jesus' death, but the sequence of an anointed figure being removed before the later destruction of Jerusalem and the sanctuary has made Daniel 9:26 a significant messianic text in Christian interpretation.