Isaiah 53 describes the rejected and suffering Servant who bears the sins of others, dies despite His innocence, is associated with the rich in burial, and afterward is vindicated. The New Testament repeatedly quotes and applies this chapter to Jesus.

The fulfillment passages listed here (John 18:11) illuminate the Christian application summarized as "God's will that He die for mankind." The correspondence is meaningful within the New Testament portrait of Jesus, but where the New Testament does not explicitly quote this exact Isaiah verse as fulfilled, it is best described as a theological or messianic correspondence rather than claiming more precision than the biblical writers themselves state.