Isaiah 48 emphasizes the LORD as the First and the Last and contains language of divine sending, teaching, and redemption that Christian readers have related to New Testament revelation concerning the Son.

The fulfillment passages listed here (John 1:30; Rev 1:8, Rev 17) illuminate the Christian application summarized as "The First and the Last." The correspondence is meaningful within the New Testament portrait of Jesus, but where the New Testament does not explicitly quote this exact Isaiah verse as fulfilled, it is best described as a theological or messianic correspondence rather than claiming more precision than the biblical writers themselves state.