The second part of Genesis 3:15 describes a conflict in which the serpent wounds the offspring of the woman, but the serpent itself receives the decisive blow. Christian interpretation has traditionally understood this as an early picture of Christ's victory over Satan. The suffering of the promised offspring anticipates the suffering of Christ, while the crushing of the serpent's head represents the ultimate defeat of the devil and his works.

The New Testament develops this theme explicitly. Hebrews 2:14 explains that Christ shared in human flesh and blood so that through His death He might destroy the one who held the power of death, identified as the devil. Similarly, 1 John 3:8 declares that the Son of God appeared in order to destroy the works of the devil. Christ's crucifixion therefore appears at first to be a victory for evil, yet through His death and resurrection He accomplishes the greater victory. From a Christian perspective, Genesis 3:15 provides the first glimpse of that conflict and its final outcome.