Psalm 69:20 describes reproach breaking the sufferer's heart and leaving him sick with grief. He looks for sympathy and comfort but finds none. The verse portrays not simply physical danger but the profound loneliness and emotional burden of rejection.

Matthew 26:38 records Jesus telling His disciples in Gethsemane, "My soul is very sorrowful, even to death," and asking them to remain and watch with Him. They repeatedly fall asleep, leaving Him to face His agony without the human companionship He sought. Matthew does not quote Psalm 69:20, but the correspondence is powerful at the level of righteous-sufferer typology: both passages portray deep sorrow accompanied by the absence of effective comfort.