Gilead first appears prominently in Genesis 31, when Jacob fled from Laban and traveled toward the hill country of Gilead. There Jacob and Laban made a covenant before separating.
Numbers 32 describes the tribes of Reuben and Gad requesting land east of the Jordan because the region was suitable for their livestock. Moses granted Transjordanian territories to Reuben, Gad, and half of Manasseh on the condition that their fighting men assist Israel in taking possession of Canaan.
Gilead later became the setting of events involving Jephthah, Saul, David, Absalom, Elijah, and the kings of Israel. Jeremiah's question, "Is there no balm in Gilead?" transformed one of the region's famous products into a powerful image of healing and spiritual need.