Damascus appears as early as the patriarchal narratives and later became the capital of an important Aramean kingdom. During the monarchy, the kings of Damascus repeatedly interacted and fought with Israel and Judah. Second Samuel 8:5 describes David defeating Arameans from Damascus, while later books record conflicts involving kings such as Ben-hadad and Hazael.
The prophets also addressed Damascus. Isaiah, Jeremiah, and Amos pronounced judgments concerning the city and the Aramean kingdom.
Damascus became especially important in Acts 9. Saul traveled there intending to arrest followers of Jesus, but encountered the risen Christ on the road. After entering Damascus blind, he was visited by Ananias, regained his sight, was baptized, and began proclaiming Jesus.