Carchemish enters the biblical narrative during the final decades of the kingdom of Judah. Second Chronicles 35:20 describes Pharaoh Necho traveling north toward Carchemish when King Josiah confronted him at Megiddo. Josiah was mortally wounded in the resulting battle.
Jeremiah 46:2 explicitly refers to the later Battle of Carchemish, where Nebuchadnezzar king of Babylon defeated the Egyptian army of Pharaoh Necho in the fourth year of Jehoiakim.
The Babylonian victory was historically important for Judah because it established Babylon as the dominant imperial power in the region. The subsequent Babylonian interventions in Judah ultimately culminated in the destruction of Jerusalem and the exile.