John 2:1-11 places Jesus, His mother, and His disciples at a wedding in Cana of Galilee. When the wine ran out, Jesus instructed servants to fill six stone water jars. The water became wine, which John identifies as the first of Jesus' signs.
Jesus later returned to Cana in John 4:46-54. While there, a royal official from Capernaum asked Him to heal his son. Jesus declared that the son would live, and the healing occurred at the same hour.
John 21:2 also identifies Nathanael as being from Cana in Galilee. The village is therefore associated both with Jesus' early signs and with one of His disciples.