Genesis 10:10 lists Calneh among the cities associated with Nimrod's kingdom in the land of Shinar. Together with Babel, Erech, and Akkad, it places Calneh within the early Mesopotamian setting of Genesis.
Amos 6:2 tells its audience to consider Calneh, Hamath, and Gath while warning the complacent leaders of Israel and Judah. The prophetic argument points to cities whose political fortunes demonstrated that apparent strength could not guarantee security.
Because the geographical settings of Genesis 10 and Amos 6 differ, scholars have questioned whether both passages refer to the same Calneh.