Babylon occupies a major place in the biblical story. Genesis associates Babel with Nimrod's kingdom and the account of the Tower of Babel. Centuries later, the Babylonian Empire became the power through which the kingdom of Judah was conquered.
Nebuchadnezzar II captured Jerusalem, and successive deportations carried Judeans to Babylonia. In 586 BC Jerusalem and the Temple were destroyed. The exile forms the historical setting for important portions of Kings, Chronicles, Jeremiah, Ezekiel, and Daniel.
Babylon also acquired a symbolic role extending beyond the ancient city. Isaiah and Jeremiah pronounce judgment against Babylon, and Revelation later employs "Babylon" as an image of a wealthy and oppressive world power destined for divine judgment.