Urkesh is not explicitly mentioned in the biblical text.
Its relevance to biblical history is geographical and cultural. The city belonged to the wider northern Mesopotamian world through which important ancient routes connected Syria, Anatolia, and Mesopotamia.
The patriarchal narratives preserve connections with northern Mesopotamian places including Harran and Aram-Naharaim. Urkesh provides archaeological evidence for the complex urban cultures that existed in this broader region.