Tarshish appears repeatedly in biblical descriptions of maritime commerce. Ships of Tarshish became proverbial for long-distance seafaring and valuable cargo.
Ezekiel describes Tarshish trading silver, iron, tin, and lead with Tyre, evidence that has played an important role in attempts to identify the region.
Jonah went to Joppa and boarded a ship bound for Tarshish in an attempt to flee from the command to preach at Nineveh. In the narrative, Tarshish functions as a distant destination in the opposite direction from Jonah's assigned mission.
Isaiah and the Psalms also use Tarshish as an image of distant maritime peoples and commercial power.