The Old Testament records extensive interaction between Israel and the Aramean kingdoms. Aram-Damascus became particularly important during the divided monarchy.
Elijah was instructed to anoint Hazael as king over Aram, and Elisha later interacted repeatedly with Aramean rulers and military commanders, including the healing of Naaman.
During the Syro-Ephraimite crisis, Rezin of Damascus allied with Pekah of Israel against Judah. Assyria subsequently conquered Damascus.
In the New Testament, Damascus remained important, while Antioch in Roman Syria became a major center of the Christian mission. Believers were first called Christians at Antioch, and Paul and Barnabas were sent from the church there.