Pharaoh ordered Hebrew male infants to be thrown into the Nile. Moses' mother instead placed him in a basket among the reeds at the riverbank, where Pharaoh's daughter discovered him.
During Moses' confrontation with Pharaoh, the Nile became the setting of the first plague. Its waters were struck and turned to blood, demonstrating God's judgment upon Egypt.
The prophets later used the Nile in oracles concerning Egypt. Isaiah, Jeremiah, and Ezekiel describe the river and its waters in connection with Egyptian agriculture, commerce, political pride, and divine judgment.