Genesis includes Nineveh among the great cities associated with ancient Assyria. During the monarchy, Nineveh became closely connected with the Assyrian power that threatened and conquered much of the biblical world.
After his unsuccessful campaign against Jerusalem, Sennacherib returned to Nineveh. Second Kings records that he was later assassinated while worshiping in the temple of his god.
The book of Jonah centers upon God's command that Jonah preach against Nineveh because of its wickedness. After Jonah eventually proclaimed the warning, the Ninevites repented, and the threatened destruction was withheld.
The prophet Nahum later announced Nineveh's downfall. The city fell to a coalition of Babylonian and Median forces in 612 BC, bringing the Assyrian imperial center to an end.