Genesis 10 places Calah among the important cities of ancient Assyria and Mesopotamia. The Hebrew text has generated discussion concerning whether Nimrod or Asshur is the subject of the statement describing the construction of Nineveh, Rehoboth-Ir, Calah, and Resen.
Although Calah receives little direct attention elsewhere in the Bible, it became one of the principal administrative and military centers of the Assyrian Empire that later dominated the kingdoms of Israel and Judah.
Assyrian kings who ruled from or developed Kalhu conducted campaigns throughout the Levant, and inscriptions and artworks recovered from the city contain important evidence concerning biblical Israel.