Luke records the angel Gabriel being sent to Nazareth to announce to Mary that she would conceive and bear Jesus. After Jesus' birth at Bethlehem and the family's subsequent experiences, He was raised at Nazareth.
Jesus became so closely associated with the town that "Jesus of Nazareth" became one of His most familiar designations.
At the beginning of His ministry, Jesus returned to Nazareth and taught in the synagogue. Luke describes Him reading from Isaiah and declaring the Scripture fulfilled, after which opposition arose among those who had known Him.
Nathanael's question, "Can anything good come out of Nazareth?" reflects the town's apparent lack of prominence rather than evidence that the settlement did not exist.