Abraham's family retained strong connections with upper Mesopotamia after Abraham departed for Canaan.
Genesis 24 records Abraham sending his servant to his country and kindred to obtain a wife for Isaac. The servant traveled to Aram-Naharaim, to the city of Nahor, where he met Rebekah at a well.
Jacob later traveled to the same broader region and lived with Laban in Paddan-Aram before returning to Canaan with his family.
Aram-Naharaim appears again during the period of the judges, when Israel was oppressed by Cushan-rishathaim, king of Aram-Naharaim, before being delivered under Othniel.