Abraham's family originated in the Mesopotamian world. Genesis describes Terah taking Abram, Sarai, and Lot from Ur of the Chaldeans toward Canaan and settling at Harran. Abraham later sent his servant to the region of his relatives to obtain a wife for Isaac.
Acts 7 describes the God of glory appearing to Abraham while he was in Mesopotamia before he lived in Harran.
The Old Testament history of Israel was profoundly affected by Mesopotamian powers. Assyria conquered the northern kingdom of Israel, while Babylon later conquered Judah, destroyed Jerusalem and the Temple, and carried many Judeans into exile.
Acts 2:9 lists residents of Mesopotamia among the Jewish pilgrims who heard the apostles speaking in their own languages at Pentecost.