Genesis 10 lists Cush as a descendant of Ham and associates him with several peoples. The same chapter also identifies Nimrod as a son or descendant of Cush, creating interpretive questions because Nimrod's kingdom is associated with Mesopotamia.
Elsewhere in Scripture, Cush generally represents the African region south of Egypt. Isaiah describes messengers traveling from Cush and refers to the political relationship between Cush and Egypt during the period of Assyrian expansion.
Second Kings and Isaiah mention Tirhakah, king of Cush, during Sennacherib's campaign against Judah. Tirhakah is identifiable with Taharqa, who became one of the rulers of Egypt's Kushite Twenty-fifth Dynasty.
The biblical references therefore connect Cush not merely with distant geography but with the international political world encountered by Judah.