Paul and Barnabas reached Pisidian Antioch after traveling inland from Perga. Acts 13:14 records that they entered the synagogue on the Sabbath. When invited to speak, Paul presented a sweeping account of Israel's history culminating in the proclamation of Jesus as the promised Savior and in His resurrection.
The message attracted substantial interest, including among Gentiles. Opposition subsequently developed, and Paul and Barnabas declared that they would turn toward the Gentiles. Acts 13:49 states that the word of the Lord spread throughout the region.
After persecution forced them from the city, the missionaries later returned to strengthen the disciples. Paul recalled the persecutions he experienced at Antioch, Iconium, and Lystra in 2 Timothy 3:11.