Anguish is extreme distress or suffering of body, mind, or spirit, including excruciating pain, grief, remorse, despair, confusion, and anxiety. Its underlying biblical imagery is pressure, narrowness, or being compressed into a confined place.
Scripture uses anguish for the pains of childbirth, distress resulting from sin and wickedness, the oppression of slavery and Assyria, and the anxiety of Christian love over the sins of fellow disciples.
The Hebrew and Greek terms behind “anguish” include ideas of being straitened, pressed, twisted with pain, afflicted, and held together by distress.