The whirling, twisting composition of elongated figures creates a confusing mass, possibly alluding to the complexity of life. The figures appear unbound by the laws of gravity, and the feet of the two figures carrying Jesus seem to barely touch the ground. These figures have been interpreted by many as angels, carrying Christ to heaven. The single, small white cloud at the top left is commonly understood as representing the presence of the Holy Spirit.
The overwhelming sense of loss and anguish of the figures is strongly conveyed in their expressions, and is strengthened by the absence of any figure at the center of the composition, where instead, the hands of several of the figures come together, as do the legs of Mary and Jesus. This space has commonly been understood as representing Mary's sense of emptiness upon losing her son. The figure at the right edge, whose drab, earthy-colored clothing, makes him seem out of place, is a self-portrait by Pontormo, a single earthly being bearing witness to this spiritual scene.
In this masterpiece, Pontormo's Mannerist style fully realized. He adopts vibrant, saturated hues to illuminate figures in serpentine poses. His characters are removed from any sort of naturalistic setting, being placed rather within a shallow, flattened space. Pontormo has also removed the cross from the scene, instead merely suggesting its form through the arrangement of the figures. The focuses here then is on the dramatic emotions of the scene rather than one more Deposition narrative. Gone too are other markers of reality, such as blood, dirt, or the crown of thorns. The only indication of Christ's death is the slight grey pallor that affects his skin, noticeable in contrast with the clear, crisp colors used in the rest of the work. This palette was most likely inspired by that used by Michelangelo for the ceiling of the Sistine chapel. Likewise, Christ's twisting body recalls Michelangelo's 1498 Vatican Pietà.
This painting is oil on wood and is the Church of Santa Felicita, Florence, Italy.