This lush work presents Madonna as both the queen of fertility and an icon of purity, offering a typical synthesis of classical pagan and Renaissance Christian ideals. The fruit, coral, and abundance of greenery around the arch stand for life, nature, and fecundity. Fruit had also connoted the cycle of the seasons since ancient times, both for obvious reasons and because of its connection to the myth of Persephone and the pomegranate. (Hades had tricked Persephone into eating pomegranate seeds while she was his captive in the underworld, binding her to remain below the earth for part of the year, thus creating the winter months during her absences.) At the same time, fruit has traditionally refered to purity, in particular melons, an image strongly related to the rituals of cleansing in Christian ceremony. The presence of the apples nuances the work's thematic scope further, representing not only fertility but also temptation and the fall, through its connection to the story of Adam and Eve. This may subtly position Madonna and child as Adam and Eve, a theory reinforced by the presentation of Saint Elizabeth as a patron Jewess with a yellow turban.
This altarpiece portrays a man reputed to be Francesco II Gonzaga in adoration of the Madonna and Child. Opposite Francesco is Saint John the Baptist, who holds a cross and a cartouche with a Latin inscription. His mother, Saint Elizabeth, the protector of Francesco II's wife Isabella d'Este, is also present, wearing a yellow turban. Saint Michael, Saint Longinus, Saint Andrew and Saint George are lined up to the sides of the Madonna and infant Jesus. The Virgin sits on a throne inscribed with the phrase REGINA/CELI LET ALLELVIA, meaning "Queen of Heaven, rejoice, Hallelujah." The baby Jesus holds red flowers, while circling around and behind them is an arch strewn with leaves and fruits, with a shell and red coral centerpiece.
This work of tempera on canvas is in the Louvre Museum, Paris, France.